Monday, October 31, 2011

GameStop testing the waters of being an Android tablet retailer

GameStop

Not to long ago a rumor popped up that video game retailer, GameStop -- would be developing their own Android tablet to sell in their retail locations. Seems a portion of the rumors were true at this point as GameStop has now reportedly teamed up with Asus, Acer, and Samsung to offer up 'specialized' Android tablets pre-loaded with seven quality Android games and support for the GamesStops own tablet controller.

Right now, its been suggested to be a pilot program so not all Gamestop locations will these tablets available but who knows? If all goes well with the pilot Gamestop could widen the availability in an effort to attract more customers. Would you really buy a tablet from GameStop though? Not sure they'd be first on my places to shop when scoping out a new tablet.

Source: WSJ via: TechCruch


Source: http://feedproxy.google.com/~r/androidcentral/~3/EcphkQRteW8/gamestop-testing-waters-being-android-tablet-retailer

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PFT: Fox not ready to name Broncos' starter yet

Super Bowl XLVGetty Images

It?s the midpoint of the season, sort of.? Eight weeks are in the books, but only eight teams have played eight games.? For the other 24, the season won?t hit the turn until next week.

And while we?re starting to get a feel for the good teams and the bad teams and the in-between teams, the any-given-Sunday vibe remains alive and well ? and the fortunes of teams can change quickly, for good or bad.

Until we crown a champion, we can dabble only in a series of snapshots as to where teams are right now.? Here are 10 of them, plenty of which may fade to black by the time January rolls around.

1.? Super Bowl rematch coming?

In August, as teams scrambled to slap together game-ready rosters without the benefit of an offseason program or traditional two-a-day workouts, it was believed that the teams who played deep into the 2010 season would have a real benefit.

And the two teams that played the deepest presumably had the biggest benefit.

From the start, the Packers showed that they?d be able to pick up right where they left off.? For the Steelers, they needed a month to find their groove, but they?ve found it in a huge way, with four straight wins punctuated by a table-turning, trend-reversing victory over Tom Brady and the Patriots, highlighted by defensive coordinator Dick LeBeau?s long-con rope-a-dope in which he convinced the Pats based on years of stubbornness that the defense wouldn?t change despite chronic struggles against offenses that spread things out and quarterbacks that could make decisions faster than the Steelers could get to the quarterbacks.

Now, nearly two months into the season, the Steelers and Packers appear to be on a collision course for a rematch, 18 years after the last time the two Super Bowl teams got back together for a second straight year.

Yes, everything is subject to change.? But when the dust settles on the 2011 season, there?s a chance that, at the very top, there will be no change at all.

2.? Eagles may have something to say about that.

After Sunday night?s thrashing of the Cowboys, there?s a new team that could disrupt Green Bay?s run to the Super Bowl.? And it?s the team that many were ready to hand the Lombardi without even playing the season.

The Eagles finally put it together on both sides of the ball in that 34-7 win over the Cowboys, and if the Eagles can keep it up they could beat the Packers in Green Bay in January.

Tony Dungy of Football Night in America pointed out after the game that the Eagles match up well with the Packers.? Indeed, the Eagles nearly knocked off the Packers in the wild-card round last year.

This year, the Eagles would be the underdog.? It?s a role they seem to relish much more than being dubbed a Dream Team.

3.? Ravens may have something to say about it, too.

Yes, they lost to the Jaguars a week ago.? Yes, they fell behind the Cardinals by three touchdowns on Sunday.? But the Ravens still have the pieces to put together a deep run into the playoffs, and they play up (and, unfortunately for them, down) to the level of the competition.

The Ravens match up well with the best teams in the conference, as long as they can get past the Steelers.? And they can go a long way toward getting past the Steelers if they can beat them next Sunday night in Pittsburgh.

Either way, the Steelers and Ravens seem destined to play again in January, for the third time in four years.? And the Ravens could be the only AFC team that could defeat the Steelers come the postseason, whether the game is played in Maryland or Pennsylvania.

4.? Tony Dungy said it the right way.

On Sunday, Bill Cowher said he doesn?t ?plan? to coach next year, and that he ?plans? to be in the same seat at CBS next year.? It?s a different twist on Jon Gruden?s approach to keeping his name out of circulation during a season.? Gruden signed an ?exclusive? contract with ESPN, and ESPN won?t say whether ?exclusive? means he can?t leave the network for a coaching job.

Neither man has said unequivocally that he won?t be coaching in 2012.? Tony Dungy showed them how to do it during Football Night in America, stating without doubt or ambiguity or wiggle words that he won?t be coaching next year.

So until Cowher and Gruden follow suit, they?ll be regarded as potential candidates for coaching jobs once January comes around.

5.? Chris Johnson is doing it the wrong way.

It?s hard to pinpoint the reasons for Titans running back Chris Johnson?s struggles.? Apart from the holdout and the new offense and the new offensive coordinator and the new quarterback, one thing is clear:? Johnson lacks the explosiveness that we used to see on a weekly basis.

It was obvious today when Johnson caught a pass and had some space with which to operate, after weeks of taking a handoff and being swallowed up by defenders before he could make it to daylight.? The old Chris Johnson would have rocketed to the endzone untouched.? The new Chris Johnson was swallowed up by defenders.

Something?s wrong with Johnson, and the question isn?t whether he?ll get it back this year.? The question is whether he?ll get it back ever.

6.? Time for a new position for Tebow.

I?ll admit it.? I was caught up in the Tebow story from last week.? Making the dramatic closing moments of the home-away-from-home game at Miami even more compelling was the fact that Tebow had been so terribly awful in the three-plus quarters before the offense woke up.

But Tebow managed to take down one of the worst teams in the league.? Sunday?s game at home against the Lions showed that Tebow simply isn?t ready to be an NFL quarterback.

It?s easy to say that he?s a work in progress.? But not every unfinished painting becomes a masterpiece.? Tebow, once fully developed, could be a .500 quarterback at best.

And that means it?s time for the Broncos to consider their alternatives.? The ultimate team player probably would move to a new position, especially if no other team wants to let him play quarterback.? But maybe it simply won?t work to take a guy who had been a quarterback and move him to a new spot on the same team.? Maybe the Broncos simply need to dump him after the season.

Either way, this experiment is well on its way to failing.? After a few more weeks ? and a few more damning columns in the hometown paper ? the Tebowmaniacs in Denver likely will agree.

7.? Temporary end of the bye-week blues.

Through Week Seven, teams emerging from byes were 3-9.? In Week Eight, the teams with byes last Sunday won five and lost only one.

It was believed that the five days off mandated by the labor agreement had been a factor in the 25-percent winning percentage.? But now, with the total success rate up to 40 percent, it?s hard to tell whether the time off actually hurts.

It definitely didn?t hurt the Eagles, especially since Andy Reid is now 13-0 after the regular-season bye.

Moving forward, count on the teams that lost to look at the things done by the teams that won in the hopes of finding a way to win after the bye week in 2012.

8.? Breaking a ?Suck for Luck? deadlock.

So with the Colts at 0-8 and the Dolphins at 0-7 and their paths not crossing in 2011, plenty of readers have asked for more information about the procedure that would apply if the two teams finish 0-16.

Several times in recent years, draft order has been determined by a coin flip.? So could the ability to draft Andrew Luck be determined by a rudimentary game of chance?

In this case, that most likely won?t happen, since the Colts and Dolphins are in the same conference.

First, the strength of schedule would be compared.? That means the total wins and losses of the Colts? opponents would be compared to the total wins and losses of the Dolphins? opponents.? If the numbers are the same, the process would move on to the next step.

Second, the division or conference tie-breakers apply, if applicable.? In other words, the various steps that would be used to determine a wild-card berth would be employed to determine the ?better? (and thus the ?worse?) team.? This would ultimately bring into play the following specific and detailed factors that surely would produce a winner (i.e. loser):? best combined ranking among conference teams in points scored and points allowed; best combined ranking among all teams in points scored and points allowed; best net points in conference games; best net points in all games; best net touchdowns in all games.

If each of those steps results in a tie, the final step would be a coin flip.? But, surely, the two teams won?t tie on each of those specific factors.

Coin flips for draft picks happen when the two tied teams are in different conferences.? In those cases, the factors are strength of schedule and coin flip.

So in a Colts-vs.-Dolphins showdown for Luck, someone will ?win? the pick based on losing as to one of the various factors listed above.

9.? ?Skins could make a run for Luck.

Though they have three wins, the Redskins? performance over the past several weeks suggests they won?t have many more.? And that could cause the Redskins to plunge toward the Andrew Luck splash zone.

Even if the Redskins lose the rest of their games, they most likely won?t ?earn? the top pick.? Still, the closer they are to the top of the order, the less it will take to finish the climb via trade.

And if Luck decides he doesn?t want to play for the team that finishes in the first spot, and if he determines that he?d like to play for the Redskins, who knows?? Mike Shanahan could get the best quarterback since the one with whom Shanahan won a pair of Super Bowls in Denver.

10.? League needs to expand reviewable plays.

As the NFL gradually expands its use of instant replay, the league needs to be willing to consider whether further changes are needed.? The most recent tweak to the system seems to cry out for a more radical overhaul.

Late in the Patriots-Steelers game, with New England trailing by six, quarterback Tom Brady was hit, forcing a fumble.? During the scramble for the ball, safety Troy Polamalu dove for it, deftly slapping the thing hard across the goal line.? The ball ultimately rolled out of the back of the end zone for a safety.? In real time and at full speed, it was hard to see that Polamalu whacked the ball toward the two-pointer.? The replays revealed that Polamalu had indeed pushed the ball into the end zone.

But when referee Mike Carey reviewed the play, since it involved a score, Carey had no power to overturn the non-call on the field as it related to Polamalu?s punching of the ball, because that specific action is not on the pre-set list of reviewable plays.

Though the play would have been subject to a booth-initiated review even if it had happened before the 2011 season, given that it happened in the final two minutes of the game, the league?s expanded commitment to getting it right compels the league to ditch the list of specifically reviewable actions and to make everything reviewable, with specific exceptions carved out.

If the overriding goal is indeed to get it right, the league should exempt from review only those judgment calls made based on a three-dimensional observation of the action that can?t and shouldn?t be second-guessed by a two-dimensional representation of it.? Other than pass interference and the question of whether a receiver was in the vicinity of a pass being assessed for intentional grounding, there are few (and possibly no) pure judgment calls.? Thus, once the referee goes under the hood to review a play, he should be able to change the outcome based on anything he sees that should have been seen in real time.

The concern about prolonging the game shouldn?t matter.? If, on scoring plays and all plays occurring with fewer than two minutes in each half, the referee watches the entire play for anything that could be overturned, the delay already has been injected into the process.? The only remaining question is whether the referee will be permitted to fix any error that he sees.

Source: http://profootballtalk.nbcsports.com/2011/10/31/john-fox-not-ready-to-name-broncos-starter-yet/related/

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Sunday, October 30, 2011

NYC museum limits visitors in bathtub-like artwork (Providence Journal)

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culturemap: Halloween stats that scare: Texas is the No. 1 state in the country for pet costumes ? and really loves candy corn http://t.co/2oktwiHB

Twitter / CultureMap Houston: Halloween stats that scare ... Loader Halloween stats that scare: Texas is the No. 1 state in the country for pet costumes ? and really loves candy corn

Source: http://twitter.com/culturemap/statuses/130426802345750529

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Apple Products That Steve Jobs Fans Love the Most (The Atlantic Wire)

Earlier this week, Apple published a fan-made memorial to Steve Jobs, where Apple customers were invited to e-mail their thoughts and feelings on the deceased CEO so that they could be shared with the world (presumably after being vetted by the company, of course). Clearly, Jobs?devotees love the products he made: nearly 20 percent of respondents mentioned specific Apple devices in their tributes. So blogger and programmer Neil Kodner decided to do a computer analysis on which words were mentioned how frequently. Included in his analysis was the number of times each major Apple product was mentioned. Thus, we can answer that burning question: For which products do Apple fanatics love Steve Jobs the most?

Related: What Techno Goodies to Expect from Steve Jobs Today

Charted above are the number of references to specific Apple products as found by?Kodner. The product most often mentioned was the Mac with 2101 references found altogether, followed by iPhone, iPod, and iPad. (Alternate names for products under the Mac personal computer line, such as?Macintosh, MacBook, and iMac, were groups under the "Mac" heading.) Those 2000s-era iDevices do pretty well against the Mac, first introduced in 1984 considering they have "been out a fraction of the time the Mac has been available," Kodner notes.?After that we see people nodding toward several discontinued Apple products, like Apple II, Lisa, and LaserWriter (that's Apple's printer from the '80s), though many more current Apple products, like iTunes, Apple TV, and iMovies, get some love. Curiously, of the 33 mentions of Newton, Apple's personal assistant device from the 1990s, "only a handful of those were about the actual Apple product ? most were comparing Steve Jobs to [Isaac] Newton himself," Kodner writes. The historical figure that Jobs was most often compared to? That would be Henry Ford, with 189 mentions.

Source: http://us.rd.yahoo.com/dailynews/rss/applecomputer/*http%3A//news.yahoo.com/s/atlantic/20111027/tc_atlantic/appleproductsstevejobsfanslovemost44210

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White House to review Energy Department loans (AP)

WASHINGTON ? On the defensive over a half-billion-dollar loan to a now-bankrupt solar company, the White House on Friday ordered an independent review of similar loans made by the Energy Department, its latest response to rising criticism over Solyndra Inc.

The announcement came as House Republicans prepared for a possible vote next week to subpoena White House documents related to the defunct California company.

White House officials said the review would assess the health of more than two dozen other renewable energy loans and loan guarantees made by the Energy Department program that supported Solyndra. Congressional Republicans have been investigating the company's bankruptcy amid embarrassing revelations that federal officials were warned it had problems but nonetheless continued to support it, and sent President Barack Obama to visit the company and praise it publicly.

"Today we are directing that an independent analysis be conducted of the current state of the Department of Energy loan portfolio, focusing on future loan monitoring and management," White House chief of staff Bill Daley said. "While we continue to take steps to make sure the United States remains competitive in the 21st century energy economy, we must also ensure that we are strong stewards of taxpayer dollars."

Daley said the review would be conducted by former Treasury official Herb Allison, who oversaw the Troubled Asset Relief Program, part of the 2008 Wall Street bailout. The review would not look at the Solyndra case but would evaluate other loans worth tens of billions of dollars and recommend steps to stabilize them if they appear to have problems like the loan to Solyndra.

Energy Secretary Steven Chu said in a statement that he welcomed the White House review.

House Republicans are preparing to ramp up their investigation of Solyndra, which is proving a political headache for the White House and providing fodder for opponents of Obama's renewable energy agenda.

The White House has already refused a request by the Republican-controlled House Energy and Commerce Committee for all its internal communications about Solyndra, which closed its doors and filed for bankruptcy protection earlier this year, costing 1,100 jobs.

GOP Reps. Fred Upton of Michigan and Cliff Stearns of Florida said Friday a subpoena was necessary because the White House has denied its requests for documents. Upton chairs the Energy and Commerce panel, while Stearns leads a subcommittee on investigations. Recently released emails and other documents show that White House officials participated in decisions regarding the Solyndra loan.

"What is the White House trying to hide from the American public?" Stearns and Upton asked in a joint statement. "It is alarming for the Obama White House to cast aside its vows of transparency and block Congress from learning more about the roles that those in the White House and other members of the administration played in the Solyndra mess."

The panel is seeking documents that might shed light on actions by White House officials in connection with the original 2009 loan to Solyndra as well as a restructuring of the deal that took place earlier this year.

Solyndra, of Fremont, Calif., was the first renewable-energy company to receive a loan guarantee under a stimulus-law program to encourage green energy and was frequently touted by the Obama administration as a model. Obama visited the company's headquarters last year, and Vice President Joe Biden spoke by satellite at a groundbreaking ceremony.

The Obama administration has released thousands of emails ? but withheld thousands more ? concerning the $528 million loan. To date, the administration says it has produced 70,000 pages, participated in nine briefings for congressional committee staff and provided testimony at four House committee hearings.

White House counsel Kathryn Ruemmler has previously said that the committee leaders' request for more documents has implications for executive branch confidentiality.

"It has been well-established for decades that the president has a strong constitutionally rooted interest in preserving the confidentiality of executive branch deliberative communications," Ruemmler wrote the committee this week.

The White House also has said it would not release Obama's BlackBerry messages ? which if released would be a presidential first.

Any subpoena of White House records could trigger a claim of executive privilege by the Obama administration and elevate the political stakes, although the issue could also be resolved through negotiations.

The loan is being investigated by two House committees, which have released Solyndra-related documents from federal agencies including the Energy and Treasury departments and the Office of Management and Budget.

Solyndra is under criminal investigation by the FBI. Inspectors general at the U.S. Treasury and the Energy Department also are investigating.

The Energy Department program was designed to guarantee private bank loans to companies that were developing renewable energy, with some direct loans by the government expected when private financing wasn't available. In practice, most of the financing has been through the government.

Of the 33 deals that have been completed so far, 26 were direct loans by the government, including the one to Solyndra, said Energy Department spokesman Damien LaVera. Only seven were completed though private banks.

___

AP Special Correspondent David Espo contributed to this story.

Source: http://us.rd.yahoo.com/dailynews/rss/uscongress/*http%3A//news.yahoo.com/s/ap/20111028/ap_on_go_co/us_solar_investigation

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Saturday, October 29, 2011

After poor debates, Perry may skip some in future (The Arizona Republic)

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PFT: Publicist denies T.O. attempted suicide

Chicago Bears v Tampa Bay BuccaneersGetty Images

We?re checking in with teams as they hit their bye week. ?Or at least we are trying to.

Next up: The Chicago Bears.

Familiar position

Lovie Smith told everyone to calm down after the team?s loss to the Lions on Monday Night Football in Week 5. ?He pointed out that if the team could beat the Vikings and Bucs, they would be 4-3 just like last year at the bye.

Give Smith credit: That?s exactly what happened. ?After a?tumultuous?training camp and start to the season, the Bears are in decent enough shape.

The Bears season has a different feel to it after two strong efforts. They completely destroyed Minnesota, and controlled the action against the Bucs in London.

The Bears have proven capable of beating mediocre competition. They can?t beat the best NFC teams: The Packers, Saints, and Lions all have wins over Chicago.

Forte leads the way

Adrian Peterson is the best running back in the NFL. ?Matt Forte may be the most important to his team. ?Forte leads all players by a wide margin in yards from scrimmage with 1,091. ?He is just off Chris Johnson?s all time yards from scrimmage record pace.

It?s hard to overstate how good Forte is as a receiver. He has a shot to be the first running back since Marshall Faulk to put up over 1,000 rushing yards and 1,000 receiving yards in the same season. It?s no coincidence Mike Martz was involved in both seasons.

Improving passing game

Jay Cutler may have enjoyed the best two game stretch of his Bears career in the loss to the Lions and the win over the Vikings. He is looking more comfortable. His pass protection has improved from absymal to simply lame.

The offense still has to be more consistent after some early ugly outings, but it?s headed in the right direction. It?s 12th in scoring despite the 21 sacks Cutler has taken. The team has a +4 turover margin.

Safety dance

Chris Harris started the season at strong safety; he was released Thursday. Brandon Meriweather was signed for $3.25 million and now sits on the bench. The team is going young with Major Wright and Chris Conte at the position. ?This is a shaky secondary overall.

Average defense

Lovie Smith teams are supposed to be built on defense. At this stage, the Bears have been ordinary stopping opponents. Lance Briggs and Brian Urlacher are still playing at a high level, but they don?t get a lot of help. The defensive line has been decent. Julius Peppers has played at less than 100%.

Chicago?s only chance to make a postseason push is for the defense to improve dramatically.

Angling for a wild card

The Bears are three games back in the NFC North, so their only hope for a playoff spot is a wild card. They are in decent shape with wins over NFC contenders like Atlanta and Tampa Bay.

The next two weeks after the bye are huge. ?The Bears travel to Philadelphia before hosting Detroit. Sweeping those two games would put Chicago in terrific position before an oddly timed four-game tour through the AFC West.

After seven weeks, the Bears are in the mix. Their recent play indicates we?ll probably be talking about Bears tiebreakers come late December.

Source: http://profootballtalk.nbcsports.com/2011/10/27/publicist-denies-that-t-o-attempted-suicide/related/

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Friday, October 28, 2011

Video: Boeing's Q3 Earnings

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Source: http://www.msnbc.msn.com/id/21134540/vp/45045011#45045011

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From genomic data to new cancer drug

From genomic data to new cancer drug [ Back to EurekAlert! ] Public release date: 27-Oct-2011
[ | E-mail | Share Share ]

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press

New discoveries about follicular lymphoma, a currently intractable form of cancer, highlight the power of functional genomics in cancer gene discovery. A report in the Oct 28th issue of Cell, a Cell Press publication, demonstrates how genetic insights can be translated directly into therapies.

The findings are but one example of what has now become possible given the avalanche of data on cancer genomes.

"With access to tumor genomic data, suddenly we can do this; we know what has changed, and the question now is to define which changes are really important," says Hans-Guido Wendel of Memorial Sloan-Kettering Cancer Center, and senior author of this study. "With that information, we can start to develop new therapies."

Wendel's group has developed a way to target and shrinks tumors when delivered to mice with an incurable form of lymphoma. Loss of the anti-cancer protein known as EPHA7 (ephrin receptor A7) is an important driver of the disease, the new evidence shows.

"We went all the way from genomic data to a potential new drug," said Wendel. "EPHA7 was not on anyone's radar screen for lymphoma. Now it is."

Wendel's team focused their attention on a portion of chromosome 6 that is commonly lost in human patients and is related to poor outcomes. But such large-scale changes can only tell you so much. "Tumors often acquire complex genomic aberrations including gains and losses of large sections or even entire chromosomes," the researchers said. "Identifying the target gene or genes from such complex genomic changes remains a significant challenge."

They used a method called RNA interference to silence genes in that stretch of the genome. That effort led them to EPHA7, a tumor suppressor protein that is shed from the surface of lymphocytes.

It is important that EPHA7 is a soluble factor, Wendel explained. "You can purify it, put it in a bottle, and see if it can be administered as a drug."

When the researchers injected EPHA7 into mice with human tumors, those tumors shrunk. They found that a particularly effective way to deliver EPHA7 to cancer cells is to fuse it with an antibody that specifically targets lymphomas.

The researchers say EPHA7 has immediate therapeutic potential, although they intend to pursue smaller versions of the protein that might be easier to make. There is also reason to think EPHA7 may ultimately have promise for the treatment of other forms of cancer as it binds a protein with links to breast and ovarian cancer.

###



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


From genomic data to new cancer drug [ Back to EurekAlert! ] Public release date: 27-Oct-2011
[ | E-mail | Share Share ]

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press

New discoveries about follicular lymphoma, a currently intractable form of cancer, highlight the power of functional genomics in cancer gene discovery. A report in the Oct 28th issue of Cell, a Cell Press publication, demonstrates how genetic insights can be translated directly into therapies.

The findings are but one example of what has now become possible given the avalanche of data on cancer genomes.

"With access to tumor genomic data, suddenly we can do this; we know what has changed, and the question now is to define which changes are really important," says Hans-Guido Wendel of Memorial Sloan-Kettering Cancer Center, and senior author of this study. "With that information, we can start to develop new therapies."

Wendel's group has developed a way to target and shrinks tumors when delivered to mice with an incurable form of lymphoma. Loss of the anti-cancer protein known as EPHA7 (ephrin receptor A7) is an important driver of the disease, the new evidence shows.

"We went all the way from genomic data to a potential new drug," said Wendel. "EPHA7 was not on anyone's radar screen for lymphoma. Now it is."

Wendel's team focused their attention on a portion of chromosome 6 that is commonly lost in human patients and is related to poor outcomes. But such large-scale changes can only tell you so much. "Tumors often acquire complex genomic aberrations including gains and losses of large sections or even entire chromosomes," the researchers said. "Identifying the target gene or genes from such complex genomic changes remains a significant challenge."

They used a method called RNA interference to silence genes in that stretch of the genome. That effort led them to EPHA7, a tumor suppressor protein that is shed from the surface of lymphocytes.

It is important that EPHA7 is a soluble factor, Wendel explained. "You can purify it, put it in a bottle, and see if it can be administered as a drug."

When the researchers injected EPHA7 into mice with human tumors, those tumors shrunk. They found that a particularly effective way to deliver EPHA7 to cancer cells is to fuse it with an antibody that specifically targets lymphomas.

The researchers say EPHA7 has immediate therapeutic potential, although they intend to pursue smaller versions of the protein that might be easier to make. There is also reason to think EPHA7 may ultimately have promise for the treatment of other forms of cancer as it binds a protein with links to breast and ovarian cancer.

###



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-10/cp-fgd102111.php

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Sean Penn Will Direct De Niro and Kristen Wiig in The Comedian

sean-penn-robert-de-niro-kristen-wiig-slice

Back in June, we reported the rumor that Sean Penn was looking to direct the character-driven drama The Comedian, with Robert De Niro to possibly star. Now it looks like things worked out, as it was announced today that Penn will indeed be directing De Niro in the pic, and they?ve found their female lead in Kristen Wiig. The project previously caught the eye of Martin Scorsese, and centers on an aging insult comic in the vein of Don Rickles and Joan Rivers. De Niro?s character ?clings to any recognition that comes from his days as a beloved TV character as he tries to reignite his stagnant career. Sentenced to community service for hitting a heckler in the head with a microphone, the comic meets Harmony, a dazzling and defiant redhead who turns his life sideways.?

The script comes from Art Linson (What Just Happened) and comedian Jeffrey Ross. This definitely sounds like an intriguing project, and Penn?s involvement brings quite a bit of weight to the material. It?s been a while since we?ve seen De Niro take on such a nuanced and complex character, and his pairing with the massively talented Wiig is an inspired choice. Penn was last behind the camera on 2007?s excellent Into the Wild. Production on The Comedian is set to get underway next spring. [Update: We've been sent the full press release, which is now included after the jump]

sean-penn-imageHere?s the full press release:

(LOS ANGELES) October 27, 2011 ? FilmNation Entertainment announced today that they will handle international sales for THE COMEDIAN. The drama will be directed by Sean Penn (Into the Wild) and will star two-time Academy Award? winner Robert De Niro and Kristen Wiig (Bridesmaids). Written by Art Linson with Jeffrey Ross, the movie will be produced by Art Linson (Into the Wild), John Linson, Jon Kilik and Robert De Niro. Shannon Costello will be associate producing.

Production is slated to start in Spring 2012.

Jackie Burke (De Niro) is a raging comic who is past his prime. A once loved TV character in his hey day, he clings to any recognition of his former fame in the hope of reviving his now stagnant career. After being sentenced to community service for hitting an audience member in the head with his microphone, Jackie meets Harmony (Wiig), a dazzling and defiant redhead who turns his life sideways.

?We?re so excited to be working with such an amazingly talented group of filmmakers on this movie. It simply doesn?t get much better than this, especially for us New Yorkers!,? said FilmNation Entertainment?s CEO Glen Basner.

CAA will represent domestic rights to the film.

Source: http://www.rottentomatoes.com/m/1923842/news/1923842/

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Women who are CEOs of Fortune 500 companies (AP)

When Virginia "Ginni" Rometty becomes CEO of IBM Corp. and Heather Bresch the CEO of Mylan Inc. in January, they join 16 other female CEOs in the Fortune 500:

Archer Daniels Midland Co., Patricia A. Woertz

Avon Products Inc., Andrea Jung

BJ's Wholesale Club, Laura Sen

Campbell Soup Co., Denise M. Morrison

DuPont., Ellen J. Kullman

Gannett Co., Gracia C. Martore

Guardian Life Insurance Company Of America, Deanna M. Mulligan

Hewlett-Packard Co., Margaret Whitman

KeyCorp., Beth Mooney

Kraft Foods Inc., Irene B. Rosenfeld

PepsiCo Inc., Indra K. Nooyi

Sempra Energy, Debra L. Reed

Sunoco Inc., Lynn L. Elsenhans

TJX Cos., Carol Meyrowitz

WellPoint Inc., Angela F. Braly

Xerox Corp., Ursula M. Burns

Source: Fortune magazine

Fortune post on female tech CEOs:

http://postcards.blogs.fortune.cnn.com/2011/10/25/new-ibm-ceo-rometty-tech-women/

Source: http://us.rd.yahoo.com/dailynews/rss/enterprise/*http%3A//news.yahoo.com/s/ap/20111026/ap_on_hi_te/us_tec_ibm_ceo_female_ceos_list

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Thursday, October 27, 2011

Gene sequencing X Prize to focus on centenarians

Wed Oct 26, 2011 10:08am EDT

(Reuters) - A $10 million contest to see which laboratory can accurately and economically sequence 100 human genomes has been tweaked to focus on the genetics of people over the age of 100.

The competition, now sponsored by drug benefit manager Medco Health Solutions Inc, is aimed at achieving a "medical grade" standard for gene sequencing that could ultimately be used to personalize medical treatment based on a person's genetic makeup.

"All the technology that people are buying now gives slightly different answers," said pioneer geneticist Craig Venter. "That means by definition they are not good enough for diagnostics."

While quality, speed and accuracy of the testing is improving, the companies involved, including Applied Biosystems, Illumina and Complete Genomics, all have their own standards, he said.

"We are trying to help the field get to where it wants to be," said Venter, who became the first individual to have their genome sequenced in 2007. "We are working with the FDA (U.S. Food and Drug Administration) to use this as an agreed upon definition to take genomics to the next grade."

The process of selecting the 100 centenarians is now underway.

The revised competition will measure laboratory teams on accuracy, cost, speed and completeness of genome sequencing.

Teams will get the 100 genomes on January 3, 2013, and the competition will conclude on February 3 of that year.

A $10 million prize purse will be given to the first team that accurately sequences the whole genome of 100 subjects within 30 days for $1,000 or less per genome, at an error rate no greater than one per million base pairs.

"We believe this competition will be the impetus to truly usher in the era of personalized medicine," said Venter.

(Reporting by Deena Beasley; Editing by Tim Dobbyn)

Source: http://feeds.reuters.com/~r/reuters/scienceNews/~3/usojyUoFpDY/us-xprize-genomics-idUSTRE79P4GH20111026

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Hospital to name room after Bret Michaels

A Phoenix hospital is injecting a little Poison into families waiting for sick loved ones, thanks to a donation from 1980s hair band singer Bret Michaels.

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The Poison frontman plans to announce Thursday that he is donating TVs and sound systems for a waiting room at the St. Joseph's Barrow Neurological Institute, where he was treated in April 2010 for a brain hemorrhage. The equipment will allow families to relax and listen to music.

In return, the waiting room will be named after Michaels.

He was also treated at the hospital earlier this year for a procedure to fix a hole in his heart. Doctors discovered the hole when they treated him for the brain hemorrhage.

Michaels says in a statement that the room will be "warm and hip."

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://today.msnbc.msn.com/id/45028293/ns/today-entertainment/

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Delta falls short on higher costs, weaker traffic (AP)

MINNEAPOLIS ? Delta will be a smaller airline next year and probably more expensive for passengers, too.

The nation's second-biggest airline said on Tuesday that it will reduce flying through the rest of this year and into next year. CEO Richard Anderson said Delta is determined to price fares high enough to cover fuel costs, which rose by $1 billion in the third quarter compared to a year ago.

All the big airlines except Southwest raised fares by up to $5 each way on Monday, for the second time in a week. With Southwest sitting out the increase, it may not stick. But the attempt shows how aggressively airlines are jumping at any opportunity to raise fares.

Delta executives said they expect high fuel prices and an uncertain economy to continue into next year.

In the past, airlines struggled to make money in a weak economy or when fuel prices rose. Now, they appear committed to raising prices or cutting back on flying to stay profitable.

Delta cut flying by 1 percent in the most recent quarter, plans to cut as much as 5 percent through the rest of the year and as much as 3 percent next year. Its third-quarter yield ? one way of measuring fares ? rose 11 percent compared with a year earlier. Traffic fell slightly, although Delta said business travel, which generates more profit, remained strong.

The result was net income of $549 million, or 65 cents per share, up by 50 percent from $366 million, or 43 cents, a year earlier. Revenue rose 10 percent to $9.8 billion. If not for losses from fuel hedging and other items, Delta would have earned 91 cents per share. That was 3 cents less than expected by analysts surveyed by FactSet.

Delta said it expects to be profitable in the fourth quarter, too.

"We've had good success in passing on high fuel costs through ticket prices at Delta," Anderson said on a conference call. Higher revenue ? mostly from fares ? covered 85 percent of its higher fuel bill. "Delta must cover its fuel costs with ticket prices" like other industries such as railroads and trucking companies do with their prices, he said.

Delta said revenue from corporate travel is holding up well despite the financial crisis in Europe. Corporate travelers tend to fly more and pay more, making them especially important for airlines.

Volatile fuel prices have confounded all the big airlines. Rising jet fuel prices hurt airline profits. So most of them make financial bets on the direction of oil as insurance against that volatility. But if oil prices fall, those hedges lose value ? hurting airline profits. Delta's profit was cut by $208 million because of such volatility. Last week Southwest Airlines Co. reported a quarterly loss for the same reason. American Airlines parent AMR Corp. reported a loss last week, too, although its problems have more to do with costs that are higher than its competitors.

United Continental Holdings Inc., the only airline company that is bigger than Delta, is due to report quarterly results on Thursday.

Delta shares fell 45 cents, or 5.1 percent, to $8.46 in afternoon trading. For the year, they have dropped 32 percent.

Source: http://us.rd.yahoo.com/dailynews/rss/earnings/*http%3A//news.yahoo.com/s/ap/20111025/ap_on_bi_ge/us_earns_delta_air_lines

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Wednesday, October 26, 2011

For Obama, new focus on the piecemeal (AP)

LOS ANGELES ? The president who ran for office promising sweeping change now finds himself calling for baby steps.

Blocked by congressional Republicans yet determined to show action as he seeks re-election, President Barack Obama has scaled back his ambitions from major initiatives like universal health care, to smaller-bore programs he can do on his own or that are uncontroversial enough for Republicans to go along. Think patent reform, reducing health regulations, or helping with student loans.

Even his jobs bill has been broken into what the president calls "bite-size pieces".

The new approach, which the White House is pushing under the slogan "We Can't Wait," represents at once a pragmatic shift by an administration with limited tools to fix the dismal economy, and a recognition of political reality when the opposition controls part of Congress and an election year looms.

Obama can't afford to sit around doing nothing. But circumstances won't let him do too much. The question is whether what he's aiming for will be enough ? to help the economy, or his own political fortunes.

"I'd amend the bumper sticker to say `We can't wait, but we can't do much in the meantime,'" said Paul Light, professor of public policy at New York University. "It might be politically effective because it suggests that he's doing something that Congress isn't, but in terms of actual impacts on real policy a lot of it is pretty thin."

The White House counters that Obama is well aware that the steps he's been pushing are no substitute for legislative action. But while continuing to pressure Congress to pass portions of his $447 billion jobs package of tax credits and public works spending, the president is determined to do what he can on his own, officials said.

"It would be incorrect to suggest that we are shifting from large-scale to small-scale solutions," said White House communications director Dan Pfeiffer. "We are pushing aggressively, 24-7, for a very specific, significant, economic package, the American Jobs Act. While we are doing that and while Congress is not acting we're not waiting around twiddling our thumbs. We're doing everything in our power to improve the lives of families across this country."

So on Tuesday, with Obama in California midway through a three-day West Coast swing, the White House rolled out an initiative to challenge community health centers to hire 8,000 veterans over the next three years. Officials said it was aimed at making progress in employing veterans should Congress not make such a push through tax credits, as Obama called for in his jobs bill.

On Monday, the focus was housing, with Obama picking hard-hit Las Vegas to announce a new program to help homeowners refinance at lower mortgage rates. The issue is a huge one, but the deal was limited, affecting perhaps 1 million to 1.6 million people ? a fraction of the 11 million facing foreclosure.

And on Wednesday in Denver Obama was to announce plans to allow students to limit their loan payments.

These steps come after other recent announcements, including plans by the White House to exempt states from some of the strict requirements of No Child Left Behind, speed up payments to federal contractors, accelerate permits for select public works projects, and scrap certain rules for the health care industry.

Such initiatives are consequential, certainly, for the people or businesses affected. But they are modest compared to the ambitions of Obama's campaign, when he promised to change the very way Washington does business, or the initiatives from earlier in his term, such as the health care and financial regulation overhauls.

It's not to say Obama doesn't have major business he'd still like to accomplish.

Take immigration: the president has long wanted to tackle comprehensive immigration legislation to create a pathway to citizenship for millions of illegal immigrants. But without Congress going along, he's limited in what he can do, as he himself acknowledged Monday night at a fundraiser at the home of Melanie Griffith and Antonio Banderas.

"We have a system that is broken, and we are doing everything we can administratively to try to lessen the pain and the hardship that it's causing," the president said. "...But again, I'm going to need your help. Because we're not going to be able to get this done by ourselves."

Congress has shown only rare signs of late of giving the president what he wants, agreeing recently to three long-delayed free trade deals, as well as a bill overhauling the patent system. Republicans may well agree to some elements in Obama's jobs bill, including extending payroll tax cuts and unemployment benefits. But the outlook for major legislative achievements is dim for the rest of Obama's term, and so the White House intends to stay focused on highlighting congressional inaction and the steps Obama can take on his own. Announcements are planned weekly through the end of the year, sometimes on items so narrow they affect individual communities.

Obama's hardly the first president to go small.

Then-President Bill Clinton proposed dozens of small-bore programs such as supporting school uniforms in his successful 1996 re-election campaign, low-cost initiatives designed to appeal to targeted voters. George W. Bush promoted volunteering and foster care, issues that allowed him to trumpet his "compassionate conservative" credentials without spending too much political capital.

Executive power and the bully pulpit can be potent tools for presidents, ones that Congress and campaign-trail opponents can never take away. For Obama, hemmed in by a rambunctious House GOP majority and a Republican Party thirsting to take his job next year, they may be among the few strategies he has left.

"I do think he's going to continue to do more of this, and I do think the voters will say at least you're trying here," said Brendan Daly, former spokesman to House Democratic leader Nancy Pelosi and now a public relations executive at Ogilvy Washington. "He's the president. He's got to try to do everything he can."

___

Editors Note: Kuhnhenn reported from Los Angeles; Werner from Washington

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//news.yahoo.com/s/ap/20111025/ap_on_el_pr/us_obama_baby_steps

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Approach to access biorelevant structures by 'remodeling' natural products

Monday, October 24, 2011

There is an increasing need for pharmacological tools for biomedical and translational research applications. The field of diversity-oriented synthesis (DOS) has been very fruitful in providing access to numerous new molecules with diverse shapes and chemical structures in order to discover candidate molecules for therapeutic use. Boston University researchers, in a paper published in the journal Nature Chemistry [23 OCTOBER 2011 | DOI: 10.1038/NCHEM.1178], present a new approach to accessing new, biorelevant structures by "remodelling" natural products. In this case, they demonstrate how the natural product derivative fumagillol can been remodelled to access a collection of new molecules using highly efficient chemical reactions.

"Overall, these studies should pave the way for work to identify pharmacological tools for use in CNS research, oncology, and as anti-infective agents," said John A. Porco, Jr., professor of chemistry at Boston University. "These studies also will enable future studies to remodel additional natural product scaffolds to access novel therapeutic agents."

In the search for novel biologically active molecules, DOS strategies break through the limitation of traditional library synthesis by sampling new chemical space. Many natural products can be regarded as useful starting points for DOS, wherein stereochemically rich core structures may be reorganized into chemotypes that are distinctly different from the parent structure. Ideally, to be suited to library applications, such transformations should be general and involve few steps.

With this objective in mind, Porco and colleagues including Professor John Snyder and postdoctoral fellow Dr. Brad Balthaser successfully remodelled the highly oxygenated natural product fumagillol in several ways using a reaction-discovery-based approach. In reactions with amines, excellent selectivity in a bis-epoxide opening/cyclization sequence was obtained using the appropriate metals catalysts forming either perhydroisoindole or perhydroisoquinoline products. Perhydroisoindoles were further remodelled to other complex structures including novel benzoxazepines.

###

Boston University Medical Center: http://www.bmc.org

Thanks to Boston University Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/114553/Approach_to_access_biorelevant_structures_by__remodeling__natural_products_

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Researchers build transparent, super-stretchy skin-like sensor

ScienceDaily (Oct. 24, 2011) ? Imagine having skin so supple you could stretch it out to more than twice its normal length in any direction -- repeatedly -- yet it would always snap back completely wrinkle-free when you let go of it. You would certainly never need Botox.

That enviable elasticity is one of several new features built into a new transparent skin-like pressure sensor that is the latest sensor developed by Stanford's Zhenan Bao, associate professor of chemical engineering, in her quest to create an artificial "super skin." The sensor uses a transparent film of single-walled carbon nanotubes that act as tiny springs, enabling the sensor to accurately measure the force on it, whether it's being pulled like taffy or squeezed like a sponge.

"This sensor can register pressure ranging from a firm pinch between your thumb and forefinger to twice the pressure exerted by an elephant standing on one foot," said Darren Lipomi, a postdoctoral researcher in Bao's lab, who is part of the research team.

"None of it causes any permanent deformation," he said.

Lipomi and Michael Vosgueritchian, graduate student in chemical engineering, and Benjamin Tee, graduate student in electrical engineering, are the lead authors of a paper describing the sensor published online Oct. 23 by Nature Nanotechnology. Bao is a coauthor of the paper.

The sensors could be used in making touch-sensitive prosthetic limbs or robots, for various medical applications such as pressure-sensitive bandages or in touch screens on computers.

The key element of the new sensor is the transparent film of carbon "nano-springs," which is created by spraying nanotubes in a liquid suspension onto a thin layer of silicone, which is then stretched.

When the nanotubes are airbrushed onto the silicone, they tend to land in randomly oriented little clumps. When the silicone is stretched, some of the "nano-bundles" get pulled into alignment in the direction of the stretching.

When the silicone is released, it rebounds back to its original dimensions, but the nanotubes buckle and form little nanostructures that look like springs.

"After we have done this kind of pre-stretching to the nanotubes, they behave like springs and can be stretched again and again, without any permanent change in shape," Bao said.

Stretching the nanotube-coated silicone a second time, in the direction perpendicular to the first direction, causes some of the other nanotube bundles to align in the second direction. That makes the sensor completely stretchable in all directions, with total rebounding afterward.

Additionally, after the initial stretching to produce the "nano-springs," repeated stretching below the length of the initial stretch does not change the electrical conductivity significantly, Bao said. Maintaining the same conductivity in both the stretched and unstretched forms is important because the sensors detect and measure the force being applied to them through these spring-like nanostructures, which serve as electrodes.

The sensors consist of two layers of the nanotube-coated silicone, oriented so that the coatings are face-to-face, with a layer of a more easily deformed type of silicone between them.

The middle layer of silicone stores electrical charge, much like a battery. When pressure is exerted on the sensor, the middle layer of silicone compresses, which alters the amount of electrical charge it can store. That change is detected by the two films of carbon nanotubes, which act like the positive and negative terminals on a typical automobile or flashlight battery.

The change sensed by the nanotube films is what enables the sensor to transmit what it is "feeling."

Whether the sensor is being compressed or extended, the two nanofilms are brought closer together, which seems like it might make it difficult to detect which type of deformation is happening. But Lipomi said it should be possible to detect the difference by the pattern of pressure.

With compression, you would expect to see sort of a bull's-eye pattern, with the greatest deformation at the center and decreasing deformation as you go farther from the center.

"If the device was gripped by two opposing pincers and stretched, the greatest deformation would be along the straight line between the two pincers," Lipomi said. Deformation would decrease as you moved farther away from the line.

Bao's research group previously created a sensor so sensitive to pressure that it could detect pressures "well below the pressure exerted by a 20 milligram bluebottle fly carcass" that the researchers tested it with. This latest sensor is not quite that sensitive, she said, but that is because the researchers were focused on making it stretchable and transparent.

"We did not spend very much time trying to optimize the sensitivity aspect on this sensor," Bao said.

"But the previous concept can be applied here. We just need to make some modifications to the surface of the electrode so that we can have that same sensitivity."

Lipomi, Vosgueritchian and Tee contributed equally to the research and are co-primary authors of the Nature Nanotechnology paper. Sondra Hellstrom, a graduate student in applied physics; Jennifer Lee, an undergraduate in chemical engineering; and Courtney Fox, a graduate student in chemical engineering, also contributed to the research and are co-authors of the paper.

The U.S. Intelligence Community Postdoctoral Fellowship Program and the Stanford Global Climate and Energy Program provided partial funding for the research.

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The above story is reprinted from materials provided by Stanford University. The original article was written by Louis Bergeron.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Darren J. Lipomi, Michael Vosgueritchian, Benjamin C-K. Tee, Sondra L. Hellstrom, Jennifer A. Lee, Courtney H. Fox, Zhenan Bao. Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes. Nature Nanotechnology, 2011; DOI: 10.1038/nnano.2011.184

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/10/111024101757.htm

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Tuesday, October 25, 2011

Banks raise Greek haircut offer to 40 percent in talks: source (Reuters)

FRANKFURT (Reuters) ? Bankers have offered to stretch the voluntary haircut on Greek debt to 40 percent, while politicians demand the private sector agree to writedowns of at least 50 percent, senior German banking source said on Sunday.

Politicians, including German finance minister Wolfgang Schaeuble have asked private creditors to Greece to accept steeper writedowns on their holdings than the 21 percent losses agreed last July.

Politicians and bankers are still wrangling over how to restructure Greek debt as part of negotiations to reform the common currency.

EU officials have also demanded that banks prop up their capital cushions to meet a core tier one capital ratio of 9 percent, in a bid to make the financial system more able to withstand a restructuring of Greek debt.

Banks are seen needing just under 100 billion euros with the bulk required by banks in Greece, Spain and Portugal.

Big name banks caught in the crossfire will have to raise less than they feared two weeks ago, and should be able to raise it privately, through existing shareholders or sovereign funds, bankers and analysts said.

To meet the more stringent capital requirements, even large lenders like Deutsche Bank (DBKGn.DE) and Commerzbank (CBKG.DE) are being asked to bulk up their capital position.

Deutsche needs an additional 2 billion euros which it can raise via retained earnings, shedding risk weighted assets, and via a small capital increase if needed, the senior German banking source, who declined to be named, said on Sunday.

The private sector is still striving to reach a deal on Greek debt writedowns by Sunday, another source said.

In July, banks and insurers agreed to contribute 50 billion euros ($69 billion) to reducing Greece's debt via a debt buyback and swap agreement, which equated to a 21 percent writedown. That is now seen as insufficient to make Athens' debt sustainable.

Deutsche Bank (DBKGn.DE) analysts last week outlined a way for banks to contribute a 40 percent "haircut" on Greek sovereign debt without substantially changing the terms of July's debt-relief deal.

(Reporting By Philipp Halstrick, writing by Edward Taylor, editing by Alexander Smith/Ruth Pitchford)

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/nm/20111023/bs_nm/us_banks_haircut

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Gitanjali inaugurates gold-vending machine (Reuters)

MUMBAI (Reuters) ? Gitanjali Export Corp. said it has launched a gold coins and medallions vending machine to cash in on robust investment demand that is rivalling the thirst for jewellery in India, the world's biggest consumer.

"It has a particular significance in India, where usually such items are purchased as tokens to observe traditions on auspicious days," said Sanjeev Agarwal, CEO, Gitanjali Export Corporation.

The machine will give stock upto 36 different sizes, price points and designs ranging from 1,000 rupees to 30,000 rupees.

India is in a high demand festival and weddings quarter, including Diwali.

Gitanjali said it plans to expand the network of these machines in places with high consumer footfalls such as malls, airports and temples to provide visitors with a range of last minute purchase choices for gifting and other needs.

(Reporting by Siddesh Mayenkar; Editing by Harish Nambiar)

Source: http://us.rd.yahoo.com/dailynews/rss/india/*http%3A//news.yahoo.com/s/nm/20111025/india_nm/india601085

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Tunisians vote in first free election

Tunisians walk past bills presenting candidates standing for national elections pasted on a wall in Tunis, Saturday, Oct. 22, 2011. Tunisians on Sunday will elect an assembly that will appoint a new government and then write the country's constitution to replace a half-century-old dictatorship that was overthrown by a popular uprising on Jan. 14. (AP Photo/Amine Landoulsi)

Tunisians walk past bills presenting candidates standing for national elections pasted on a wall in Tunis, Saturday, Oct. 22, 2011. Tunisians on Sunday will elect an assembly that will appoint a new government and then write the country's constitution to replace a half-century-old dictatorship that was overthrown by a popular uprising on Jan. 14. (AP Photo/Amine Landoulsi)

Tunisians pass election wall posters in Tunis, Saturday Oct. 22, 2011. Tunisia's capital throbs with excitement as political parties hold final rallies with rock-star soundtracks ahead of the country's first truly free elections since gaining independence from France more than a half-century ago. Fears of political polarization and voter apathy seem to fall away ahead of Sunday's balloting, which is being closely watched across the Middle East. (AP Photo/Amine Landoulsi)

Electoral workers check ballot boxes at a polling station in Mnihla near Tunis, Saturday, Oct. 22, 2011. Tunis was filled with rival rallies throbbing with music as the political parties marked the end of three weeks of campaigning for the country's first truly free and multiparty elections since its independence from France in 1956. (AP Photo/Amine Landoulsi)

Electoral workers and Tunisian military carry voting boxes to a polling station in Mnihla near Tunis, Saturday Oct. 22, 2011. Tunisia's capital throbs with excitement as political parties hold final rallies with rock-star soundtracks ahead of the country's first truly free elections since gaining independence from France more than a half-century ago. Fears of political polarization and voter apathy seem to fall away ahead of Sunday's balloting, which is being closely watched across the Middle East. (AP Photo/Amine Landoulsi)

Tunisians voters stand in a line outside the poling station in Menzeh near Tunis, Sunday Oct. 23, 2011. Tunisians began voting Sunday in their first truly free elections, the culmination of a popular uprising that ended decades of authoritarian rule and set off similar rebellions across the Middle East. (AP Photo/Amine Landoulsi)

(AP) ? Tunisians began voting Sunday in their first truly free election, the culmination of a popular uprising that ended decades of authoritarian rule and set off similar rebellions across the Middle East.

Voters ? women with headscarves and without, former political prisoners, young people whose Facebook posts helped fuel the revolution ? are electing members of an assembly that will appoint a new government and then write a new constitution. They're definitively turning the page on the 23-year presidency of Zine El-Abidine Ben Ali, who was overthrown by a monthlong uprising on Jan. 14 stirred by anger at unemployment, corruption and repression.

The party expected to come out on top, Ennahda, is a moderate Islamic party whose victory, especially in a comparatively secular society like Tunisia, could have wide implications for similar religious parties in the region.

The unexpected revolution in this quiet Mediterranean country ? cherished by European tourists for its sandy beaches and desert oases ? set off a series of similar uprisings against entrenched leaders, an event now being called the Arab Spring. If Tunisia's election produce an effective new government they will serve as an inspiration to pro-democracy advocates across the region, including in next-door Libya, where longtime dictator Moammar Gadhafi was killed last week by rebel forces.

The campaign season has been marked by controversies over advertising, fears over society's religious polarization and concerns about voter apathy, but in the run-up to the vote a mood of optimism and excitement in the capital was palpable.

Soldiers were stationed in several areas to keep order, but as of mid-morning the election appeared calm.

"It's a historic day, a moment of joy and celebration. Even if I have to stand in line 24 hours, I would not give up the chance to savor this air of freedom," said Touhami Sakouhi, a former political prisoner standing in line at a crowded voting station in the poor Ettadhamen quarter of Tunis.

In the richer Tunis suburb of al-Aouina, 18-year-old language student and former protester Zeinab Souayah said, "I'm going to grow up and think back on these days and tell my children about them."

"It feels great, it's awesome," she added, in English.

The ballot is an extra-large piece of paper bearing the names and symbols of the parties fielding a candidate in each district. It's a cacophony of choice in a country effectively under one-party rule since independence from France in 1956, and where the now-popular Islamist party Ennahda was long banned.

Retired engineer Bahri Mohamed Lebid, 73, said he voted "for my religion," a sentiment common among Ennahda supporters. He described the last time he tried to vote, in 1974, when he said polling officers forced him to cast a ballot for the ruling party despite his objections.

Others expressed concern that despite its moderate public line, Ennahda could reverse some of Tunisia's progressive legislation for women if the party gains power.

"I am looking for someone to protect the place of women in Tunisia," said 34-year-old Amina Helmi, her hair free of the headscarves that some Tunisian women wear. She said she voted for the center-left PDP party, the strongest legal opposition movement under Ben Ali. She said she was "afraid" of Ennahda.

There are 7.5 million potential voters, though only 4.4 million of them, or just under 60 percent, are actually registered. People can vote with their identity cards but only at certain stations, which some fear may cause confusion during the polls.

More than 5,000 foreign observers are monitoring the vote.

Voters in each of the country's 33 districts, six of which are abroad, have a choice of between 40 and 80 electoral lists, consisting of parties and independent candidates.

A proportional representation system will likely mean that no political party will dominate the assembly, which is expected to be divided roughly between the Ennahda party, centrist parties and leftist parties, requiring coalitions and compromises during the writing of the constitution.

"This is the first time in my life I've truly voted. It is something extraordinary," said Turkane Seklani, a 37-year-old casting her ballot in polling station set up in the Bourguiba High School in Tunis. The sun was still rising as she cast her ballot soon after 7 a.m., but the capital was already humming with political activity.

She said she voted for center-left party Ettakatol, because its leader, a doctor who opposed Ben Ali in the years before the uprising, "is a good man and I find him honest and with integrity."

In the 10 months since the uprising, Tunisia's economy and employment, part of the reason for the revolution in the first place, has only become worse as tourists and foreign investors have stayed away.

Many have expressed indifference about the election out of frustration that new jobs have yet to appear and life has not improved since the revolution.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-10-23-ML-Tunisia-Elections/id-d7d2362542f64139b600180ac5b8df8e

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